# Senior R&D Scientist - Solid Dosage Development

> Eva Pharma · Giza, Egypt · Full-time · Posted 2026-06-04

**Workplace:** on_site

**Department:** R&D Business Division

## Description

EVA Pharma is hiring Senior scientist to lead the design, development, optimisation, and scale-up of Fixed Dose Combination (FDC) generic products in tablet and capsule forms. The role should demonstrate deep expertise in multi-API formulation science, compatibility assessment, and dissolution development.

Main responsibilities:

Formulation Design & Optimisation

-   Design and develop FDC tablet and capsule formulations combining two or more APIs 

-   Conduct preformulation: solubility, compatibility, polymorphism, and hygroscopicity for each API and the combination 

-   Select excipients and platforms — IR, MR, bilayer, multi-particulate — based on TPP 

-   Optimise formulations using QbD, DoE, and FMEA 

Compatibility & Stability 

-   Execute drug-drug and drug-excipient compatibility and forced degradation studies 

-   Design and run ICH stability protocols; interpret data and propose formulation adjustments 

Dissolution Development 

-   Develop and validate discriminatory dissolution methods for each API in the FDC 

-   Select biorelevant media and apparatus; investigate and resolve dissolution failures

Process Development & Scale-Up 

-   Develop manufacturing processes — wet/dry granulation, direct compression, encapsulation — suited to FDC requirements 

-   Define CPPs and CQAs; execute scale-up and process validation from lab to pilot to commercial 

Tech Transfer 

-   Prepare tech transfer packages: formulation dossier, batch records, process descriptions, in-process specs 

-   Support on-site transfer, resolve deviations, and ensure reproducible handover to manufacturing 

BE Support 

-   Contribute to BE protocol design and formulation rationale for generic FDC versus reference innovator 

-   Support interpretation of BE outcomes and propose reformulation where needed 

Scientific Guidance 

-   Provide day-to-day technical guidance to 1–3 junior scientists 

-   Review data, troubleshoot failures, and maintain up-to-date knowledge of FDC science and compendial updates

## Requirements

**Education:** 

Master's or PhD in Pharmaceutical Sciences, Pharmaceutics, or related field 

**Experience:**

 8–10 years hands-on solid dosage formulation development in pharma industry 

**Technical skills:** 

-   FDC formulation experience — tablets and/or capsules — combining two or more APIs 

-   Reformulations: solubility, compatibility, polymorphism, and stability assessment 

-   Dissolution method development and validation for multi-API systems 

-   Process development across wet/dry granulation, direct compression, and encapsulation 

-   Scale-up and tech transfer to pilot and commercial manufacturing 

-   BE protocol contribution for generic FDC products 

-   QbD, DoE, and FMEA application in formulation development 

-   Working knowledge of ICH Q1, Q6, Q8, Q9, Q10

## Apply

[Apply at Eva Pharma](https://apply.workable.com/eva-pharma/j/844E9EF397/apply)

---
Powered by [Workable](https://www.workable.com)