# VP, Clinical Operations and Data Management

> Orchard Therapeutics · London, United Kingdom (Hybrid) · — · Posted 2026-05-18

**Workplace:** hybrid

## Description

**Reporting to:** Chief Medical Officer

**Location:** London

**Job Summary**

The Vice President of Clinical Operations and Data Management (CODM) provides strategic leadership for the planning, execution, and oversight of global clinical trials. This role is accountable for delivering high-quality, compliant, patient-focused studies on time and within budget, while advancing the organization’s clinical development strategy and supporting global regulatory and commercialization objectives.

**Key Elements and Responsibilities**

·         Provide strategic and operational leadership for clinical operations and data management across programs, from study start-up through close-out, in compliance with ICH-GCP.

·         Ensure the quality, integrity, and inspection-readiness of all clinical and data management activities globally.

·         Drive cross-functional collaboration to deliver clinical trials on time and within budget.

·         Lead planning, execution, and reporting of clinical studies, ensuring alignment on timelines, deliverables, and resources.

·         Act as the primary escalation point for critical study and vendor issues.

·         Oversee study budgets, timelines, resources, and financial tracking.

·         Partner with Clinical Science, Biostatistics, and external vendors to ensure seamless delivery of:

o   Clinical documentation

o   Data management activities

·         Ensure effective coordination of regulatory submissions (e.g., IRB/ethics committees, local authorities).

·         Oversee data management strategy and execution, including database design, build, maintenance, and database lock activities, in alignment with biostatistics.

·         Ensure robust data integrity, accurate record-keeping, and compliant archiving practices.

·         Provide oversight of clinical sites, academic partners, and vendors (e.g., CROs, labs) to ensure performance, quality, and compliance.

·         Build and maintain strong relationships with investigators and key opinion leaders.

·         Lead, develop, and mentor high-performing teams.

·         Ensure delivery of high-quality study documentation to meet program timelines.

## Requirements

**Experience, Skills & Knowledge**

·         Extensive experience in clinical operations leadership within biotech/pharma.

·         Strong clinical project and program management expertise.

·         Proven track record managing CROs and external vendors.

·         Solid understanding of global regulatory requirements (ICH-GCP).

·         Experience managing budgets and resource planning.

·         Strong problem-solving skills with the ability to operate strategically and tactically.

·         Excellent leadership, communication, and stakeholder management skills.

·         Ability to thrive in a fast-paced, evolving biotech environment.

·         Experience in rare/orphan diseases and/or academic collaborations is a plus.

**Education**

-   Bachelor’s degree in Life Sciences required.
-   Advanced degree (MS, PhD, or equivalent) preferred.
-   Substantial experience leading Clinical Operations and Data Management teams.

·         Experience in rare disease; gene and cell therapy experience is a plus

## Apply

[Apply at Orchard Therapeutics](https://apply.workable.com/orchard-therapeutics/j/3F5F4A3037/apply)

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