# Principal Scientist, Biology > Rgenta Therapeutics · Woburn, United States · Full-time · Posted 2026-11-06 **Workplace:** on_site ## Description **Company Overview** Would you like to discover the next generation of medicines and see your science become therapies for patients who need them? At Rgenta Therapeutics, we are unlocking the therapeutic potential of targets that are highly disease-relevant but have historically been considered undruggable. Our proprietary RNA-targeting platforms leverage deep expertise in genomics, computational biology, screening, and chemistry to discover small molecules that modulate RNA biology, enabling us to develop transformative therapies for previously untreatable conditions. Located in the Greater Boston area, Rgenta is a vibrant, venture-backed biotechnology company driven by scientific curiosity, rigor, and a collaborative spirit. Discovering new medicines takes teams with a diversity of skills, perspectives, and approaches. Curiosity, teamwork, passion, complementary expertise, and thinking outside the box are just a few of the traits our successful drug discoverers share, and we are seeking an accomplished biologist with deep scientific expertise, eager to see their work lead to new medicines and scientific breakthroughs, to join our team. This position offers a unique opportunity to collaborate on shaping the biology strategy of our small molecule programs from early discovery through IND-enabling studies, with high visibility and meaningful impact at a pivotal stage in the company’s growth. **Position Summary **The Principal Scientist, Biology will lead in vitro and in vivo activities to identify and evaluate target dependency hypotheses, help identify preclinical models representative of target patient populations, lead biomarker strategy, and validate small molecule series. Serving as the Biology lead on one or more drug discovery programs, this individual will combine hands-on scientific expertise with strategic thinking, cross-functional collaboration, and mentorship. This role is full-time on-site and reports to the Senior Director, Biology. **Core Responsibilities** ●      **Program Leadership** ○   Serve as a Biology lead on cross-functional teams passionate about advancing small molecule drug discovery programs. ○      Manage internal research activities and external CRO partnerships to drive projects forward with high-quality, decision-enabling data. ●   **Model Development and Pharmacology** ○   Develop and validate cell-based models to support lead optimization and pharmacology profiling. ○      Help identify preclinical models that are representative of target patient populations. ○      Evaluate drug mechanism of action, as well as response and resistance, in clinically relevant models. ○      Design, execute, and analyze in vitro and in vivo pharmacology studies, utilizing PK/PD and efficacy data to drive lead optimization and support development candidate (DC) nomination. ●      **Biomarker Strategy and Regulatory Support** ○      Design and direct biomarker strategy for one or more programs, defining target engagement, pharmacodynamic, and predictive biomarkers from discovery through IND-enabling studies. ○      Prepare regulatory reports for filings, including authorship and review of the nonclinical pharmacology and biomarker sections of IND submissions. ●      **External Engagement and Mentorship** ○      Present Rgenta’s science at scientific conferences and represent the company within the broader scientific community. ○      Build and maintain relationships with academic key opinion leaders and collaborators to advance program strategy. ○      Mentor, and may supervise, research associates and scientists, fostering a culture of scientific rigor, curiosity, and growth. ## Requirements **Qualifications** ●  **Education and Experience** o   Ph.D. with postdoctoral training in genetics, cell biology, molecular biology, or a related field. o   Minimum 5-8 years of experience in the biotechnology or pharmaceutical industry, or equivalent experience. o   Proven track record of scientific excellence, as evidenced by high-impact, peer-reviewed publications. ● **Technical Expertise** o   Experience with cell line profiling, pathway signaling, assay development, and compound profiling. o      Strong understanding of genomic drivers and pharmacodynamic/predictive biomarkers. ●  **Skills and Abilities** o      Thrives in a fast-paced, dynamic environment; detail-oriented with a strong problem-solving mindset. o      Highly self-motivated and collaborative, with a high level of integrity and a commitment to quality. o      Excellent written and verbal communication skills, with the ability to collaborate effectively across functions. ## Benefits **Rgenta is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:** ·       Competitive medical, dental, and vision plans ·       Flexible Spending Accounts for medical and dependent care ·       Free Peloton app and Apple Fitness+ access ·       Weight loss programs with personalized coaching ·       Employee Assistance Program for mental health, legal, and financial support ·       Paid family leave ·       Generous paid time off including vacation, sick days, and holidays ·       401(k) program ·       Stock options for eligible employees ·       Education assistance programs ·       Access to exclusive rewards for wellness activities Rgenta is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply! Rgenta is proud to be an equal opportunity workplace and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law.  Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We’re focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best. ## Apply [Apply at Rgenta Therapeutics](https://apply.workable.com/rgenta-therapeutics/j/5C5CD1EB9A/apply) --- Powered by [Workable](https://www.workable.com)